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Dr. Rakesh K. Jain Honored With the 2014 AACR Princess Takamatsu Memorial Lectureship

March 4, 2014
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SAN DIEGO — The American Association for Cancer Research (AACR) will honor Rakesh K. Jain, Ph.D., director of the Edwin L. Steele Laboratory in the Department of Radiation Oncology at Massachusetts General Hospital in Boston, with the Eighth Annual Princess Takamatsu Memorial Lectureship at the AACR Annual Meeting 2014, to be held in San Diego, Calif., April 5-9.

Jain, who is also the Andrew Werk Cook professor of tumor biology (radiation oncology) at Harvard Medical School, is being recognized for his pioneering work in tumor biology and his leadership in developing diverse international collaborations and training the next generation of scientists. He will present his lecture, “Re-engineering the Tumor Microenvironment to Enhance Cancer Treatment: Bench to Bedside to Biomarkers,” Monday, April 7, 3:30 p.m. PT, in Ballroom 20D in the San Diego Convention Center.

Jain is renowned for his work characterizing the abnormal state of blood vessels within tumors and for proposing and then validating the groundbreaking hypothesis that “normalizing” the network of blood vessels in a tumor can improve treatment outcomes. In testing his hypothesis he made discoveries that fundamentally changed understanding about the ways in which anticancer therapeutics called antiangiogenic agents work. Developed to prevent tumor blood vessels from forming, Jain’s research showed that antiangiogenic agents can actually normalize tumor blood vessels in both animal models and cancer patients, and that this improves outcomes for patients.

Throughout his career, Jain has mentored graduate and postgraduate students from around the world from diverse backgrounds, including chemistry, molecular and cellular biology, immunology, radiology, pathology, surgical oncology, engineering, mathematics, and physics, many of whom are now leaders.

“I feel enormously honored and pleased to be chosen as a recipient of this prestigious award. I have had the good fortune of collaborating with more than 200 doctoral and postdoctoral students from diverse backgrounds, my faculty colleagues, my former and current department chairs and a highly talented technical staff, and a large number of basic scientists and clinicians from all over the world. I am grateful to all of them for making my journey as a chemical engineer into the world of solid tumors both productive and compelling,” Jain said.

The AACR Princess Takamatsu Memorial Lectureship is presented to a scientist whose novel and significant work had or may have a far-reaching impact on the detection, diagnosis, treatment, or prevention of cancer, and who embodies the dedication of the princess to multinational collaborations. Her Imperial Highness Princess Kikuko Takamatsu was instrumental in promoting cancer research and encouraging cancer scientists. She became a champion for these causes following her mother’s death from bowel cancer in 1933 at the young age of 43.

Jain’s contributions to cancer research have been recognized with numerous other accolades, including election to the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine; he is one of only 20 people ever to have been elected to all three U.S. National Academies. He also received the American Society for Clinical Oncology’s Science of Oncology Award in 2012.
Jain received his bachelor’s degree from the Indian Institute of Technology in Kanpur, India, and his master’s and doctorate degrees from the University of Delaware in Newark, Del., all in chemical engineering. Prior to joining Massachusetts General Hospital and Harvard Medical School in 1991, Jain was assistant professor of chemical and biomedical engineering at Columbia University in New York, N.Y. (1976-1978), and then rose through the ranks to become professor of chemical and biomedical engineering in 1983 at Carnegie Mellon University in Pittsburgh, Pa.



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